SPINAL TOLERANCE AND DEPENDENCE: SOME OBSERVATIONS ON THE ROLE OF SPINAL N-METHYL-D-ASPARTATE RECEPTORS AND PHOSPHORYLATION IN THE LOSS OF OPIOID ANALGESIC RESPONSES

The continuous delivery of opiates can lead to a reduction in analgesic effects.In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component.Such loss of effect, deemed to be tolerance in the present article, can be readily demonstrated in animals with repeated bolus and contin

Obesity is characterized by an increase in body weight associated with an exaggerated enlargement of the adipose tissue.Obesity has serious negative effects because it is associated with multiple pathological complications such as type 2 diabetes mellitus, cardiovascular diseases, cancer, and COVID-19.Nowadays, 39% of the world population is obese

Abstract Background Several studies have shown that prison is characterized by a higher prevalence of chronic diseases than unconfined settings.The aim of this study was to describe the characteristics and health of inmates, focusing on internal diseases.Methods We designed a specific clinical record using the Python programming language.We conside

Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the host plasma membrane, acquisition of the viral membrane and envelope proteins through budding, and formation of the HR Board core through the maturation process.Although in both immature and mature retroviruses, Gag and capsid proteins are organized as paracrystal

The article deals Engravable Bead Name Cuff Bracelet With Birthstone Gift Box with visual and verbal messages placed on the covers of weekly magazines.Rich in meanings, the message which combines the iconic and verbal elements makes it possible to analyse the relation between those two components as well as to examine multiple levels of the content